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KMID : 0381120220440091125
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Genes and Genomics
2022 Volume.44 No. 9 p.1125 ~ p.1135
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The association study between CYP20A1, CYP4F2, CYP2D6 gene polymorphisms and coronary heart disease risk in the Han population in southern China
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Liang Tiebiao
Liang Anshan
Zhang Xianbo
Wang Qi
Wu Haiqing
He Jun
Jin Tianbo
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Abstract
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Background: Coronary heart disease (CHD) is a disease that seriously harms human health. Genetic factors seriously affect the CHD susceptibility. The CYP20A1, CYP4F2 and CYP2D6 are important drug metabolism enzymes in the human body.
Objective: We aimed to explore the association between CYP20A1, CYP4F2, CYP2D6 single nucleotide polymorphisms (SNPs) and CHD risk in the Chinese Southern Han population.
Methods: Based on the ‘case?control’ experimental design (505 cases and 508 controls), we conducted an association study between 5 candidate SNPs selected from CYP20A1 (rs2043449), CYP4F2 (rs2108622, rs3093106, rs309310), CYP2D6 (rs1065852) and CHD risk. Logistic regression was used to analyze the CHD susceptibility under different genetic models. Multi-factor dimensionality reduction (MDR) was used to analyze the interaction of ‘SNP-SNP’ in CHD risk.
Results: Our results showed that under multiple genetic models, CYP2D6 rs1065852 significantly increased the CHD risk in these participants who are?≤?60 years old (OR 1.40, CI 1.07?1.82, p?=?0.013), smokers (OR 1.40, CI 1.02?1.93, p?=?0.039), or have family history (OR 1.24, CI 1.02?1.51, p?=?0.035). CYP4F2 SNPs rs2108622 (OR 0.63, CI 0.43?0.93, p?=?0.020), rs3093106 (OR 0.52, CI 0.29?0.92, p?=?0.023), and rs309310 (OR 0.55, CI 0.31?0.96, p?=?0.033) were potentially associated with the course of CHD patients.
Conclusion: Our study found that CY2D6 rs1065852 has an outstanding and significant association with increased CHD risk. Our study provided data supplements for CHD genetic susceptibility loci, and also provided a new and valuable reference for CHD drug treatment.
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KEYWORD
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Coronary heart disease, Single nucleotide polymorphisms, Case?control, Susceptibility
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